Iterative Spatial Omics: A holistic Framework for Interrogating the TME with High-Plex Spatial Multi-Omics
Time: 12:15 pm
day: Day One PM
Details:
- Integrating Spatial Proteomics, Genomics & Transcriptomics: This talk introduces a scientific framework leveraging iterative spatial multi-omics to resolve the complexity of the tumor microenvironment (TME), enabling the discovery of predictive biomarkers and mechanisms driving therapeutic response or resistance
- Insights from EBV+ vs. EBV- TME in B-cell malignancies: Using spatial proteomics, key differences in cell types, functionality, and cellular neighborhood changes between EBV-positive and EBV-negative TMEs are identified. Proximity-linked exhaustion scores are used to stratify cHL tumors, while spatial transcriptomics provides mechanistic insights for patient stratification
- What can Elucidate Bio do for you? Single-slide spatial multi-omic data generation & analysis tailored to advance biomarker discovery and therapeutic development
